Patient zero is the first patient who indicates the outbreak of a disease, and may help indicate its source and possible spread. The term was used by Dr William Darrow to refer to the spread of HIV in North America, which showed how ‘patient zero’ had infected multiple partners with HIV, and how the virus had spread across the world. Journalist Randy Shilts wrote about patient zero, Gaetan Dugas, a promiscuous flight attendant, based on Darrow’s findings.
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